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研发过程中最棘手的问题，是美术人员的频繁流失。小公司待遇有限，美术来了又走，无人接手时，波波只能亲自上阵画素材应急，这也是如今游戏里残留着多种美术风格的原因。。爱思助手下载最新版本对此有专业解读
However, Koch never credited the Hesses for their discovery of bacteriological agar, perhaps because, at the time, he failed to recognize its importance. Even after he received the insight about agar from the Hesses, Koch stuck with gelatine for years. In 1883-84, during his first medical expedition to Egypt and India to investigate cholera, he tried and failed to grow the cholera bacterium on gelatine media in the hot climate of Cairo (despite using a half-open fridge for incubation), only succeeding in the colder winter of Calcutta.